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Dynamics of PML bodies in BHK cells
Promyelocytic leukaemia (PML) nuclear bodies are present in most mammalian cell nuclei and are the target of PML-RAR-alpha oncoproteins in acute promyelocytic leukaemia where they are disrupted. These bodies contain numerous proteins including Sp100, SUMO-1, HAUSP(USP7), CBP, and BLM, and they have been implicated in aspects of transcriptional regulation or as nuclear storage depots. Here we show that there are three classes of PML nuclear bodies that can be distinguished based upon their dynamic properties in living cells. One class of PML bodies is particularly noteworthy in that it moves via a metabolic energy-dependent mechanism.
From: Muratani, M., D. Gerlich, S.M. Janicki, M. Gebhard, R. Eils and D.L. Spector. 2002. Metabolic energy-dependent movement of PML bodies within the mammalian cell nucleus. Nature Cell Biol. 4, 106-110.
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