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The peripheral dynamics of nuclear speckles is significantly reduced upon inhibition of RNA polymerase II transcription.
Inhibition of RNA polymerase II transcription by alpha-amanitin significantly reduces the dynamics on the periphery of nuclear speckles and the speckles round-up.
From: Misteli, T., J.F. Cáceres, and D.L. Spector. 1997. The dynamics of a pre-mRNA splicing factor in living cells. Nature 387, 523-527.
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